These tails are topic to several put up-translational covalent modifications, together with acetylation, solicitor law firms phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). Methylation been discovered on a spread of lysine residues in numerous histones: K4 (using the only-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, lawyer in my area K59 within the globular domain of histone H4 2 and K26 of histone H1B three Several proteins responsible for the methylation of particular residues have been characterized, and all but certainly one of these contains a SET domain