EZH1 mediates methylation on histone H3 lysine 27 and enhances EZH2 in maintaining stem cell id and executing pluripotency. Garforth SJ, Lwatula C, Prasad VR. The exception to the rule is the DOT1 family, members of which methylate K79 within the globular area of histone H3 and which are structurally not related to SET-area proteins four - 6 Current work suggests that SET-area-containing proteins methylate just a few proteins in addition to histones (see later)