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Metandienone: Pharmacology And Therapeutic Uses_Chemicalbook
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Metandienone: Pharmacology and Therapeutic Uses
<br>Metandienone, also known as methandrostenolone, is a synthetic anabolic-androgenic steroid commonly used to enhance physical performance and muscle growth. Its pharmacological properties make it effective for specific therapeutic applications, though its use remains controversial due to potential side effects.<br>
General Description
<br>Metandienone is a derivative of dihydrotestosterone (DHT) with a structure optimized for increased anabolic activity. It is classified as a Schedule III controlled substance in many regions due to its potential for misuse and dependency. The compound is typically administered orally, offering rapid absorption and systemic effects.<br>
Pharmacology
<br>The pharmacological action of Metandienone involves binding to androgen receptors in muscle cells, promoting protein synthesis and nitrogen retention. This leads to increased muscle mass and strength. Its metabolic stability allows for prolonged effects despite its short half-life in the body.<br>
Enhance Muscle Mass
<br>Metandienone is widely recognized for its ability to accelerate skeletal muscle growth by enhancing myofibrillar synthesis and reducing muscle catabolism. It is often used in sports and bodybuilding to improve physical endurance and lean tissue development.<br>
Reduces Sperm Quality
<br>Prolonged use of Metandienone can lead to suppression of natural testosterone production, which may negatively impact spermatogenesis. This effect underscores the importance of monitoring hormonal balance during treatment or usage.<br>
Mechanism of Action
<br>Metandienone exerts its effects by modulating gene expression related to muscle growth and metabolism. It increases the transcription of proteins involved in cell proliferation and repair while minimizing glucocorticoid activity, which helps preserve lean tissue during catabolic states.<br>
Therapeutic Uses
<br>While primarily associated with performance enhancement, Metandienone has been used in medical contexts to treat muscle wasting conditions, such as those caused by prolonged illness or cachexia. Its application is strictly regulated and requires careful dosing under clinical supervision.<br>
References:
<br>Chemicalbook. Metandienone: Pharmacology And Therapeutic Uses. Online. Available at: No external links provided.<br>

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